Adding Guar Gum to High-Fat Diets Ameliorates Fish Growth, Gut Histology, Gut Microbiota Composition, and Intestinal Inflammation in Common Carp.

ABSTRACT: The purpose of this research was to investigate how adding dietary guar gum to high-lipid diets affected the fish growth and gut health of common carp (Cyprinus carpio). A normal-lipid diet (5% crude lipid; control) and four high-lipid diets (10% crude lipid) with 0% (high-fat [HF]), 0.3% (GG0.3), 1% (GG1), and 3% (GG3) of guar gum were developed and fed to fish (4.53 g) for 8 weeks. The findings showed that HF induced impairment of intestinal morphology and mucosal barrier, oxidative stress, gut dysbiosis, and gut inflammation. Compared to the HF, guar gum-containing diets substantially improved gut villus height, upregulated the expression levels of nuclear factor erythroid 2-related factor 2 and zonula occludens-1, and downregulated the expression levels of toll-

SUBMITTER: Chen W 

PROVIDER: S-EPMC12811151 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature