A Methodological Review of Simulation Studies Published in Pharmacoepidemiology and Drug Safety.

ABSTRACT:

Purpose

Simulation studies are used in pharmacoepidemiology for evaluating statistical methods in a controlled setting, whereby a known data-generating mechanism allows evaluation of the performance of different approaches and assumptions. This study aimed to review simulation studies performed in pharmacoepidemiology.

Methods

We conducted a review of all papers published in the journal of Pharmacoepidemiology and Drug Safety (PDS) over the period 2017-2024. We extracted data on study characteristics and key simulation choices such as the type of data-generating mechanism used, inferential methods tested and simulation size.

Results

Among 42 simulation studies included, 34 (81%) were informing comparative effectiveness/safety studies. Twenty-two studies (52%) used sim

SUBMITTER: Muddiman R 

PROVIDER: S-EPMC12811199 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature