Adult T-cell leukemia/lymphoma in French Guiana (1990-2019): Epidemiology, clinical features, and HTLV-1 genetic diversity in the two main ethnic populations.

ABSTRACT: Adult T-cell leukemia/lymphoma (ATL) is a rare and aggressive malignancy caused by human T-cell leukemia virus type 1 (HTLV-1). French Guiana, located in northeastern South America, is a region of high HTLV-1 endemicity with a multiethnic population. We conducted a comprehensive 30-year study of ATL cases diagnosed between 1990 and 2019, capturing nearly all confirmed ATL cases in the territory (n = 137). The predominant subtypes were lymphoma (58%) and acute ATL (36%). Striking ethnic disparities emerged: 69% of patients were Maroons, and the median age at diagnosis was 43 years among Maroons versus 58 years among Creoles. Survival outcomes were uniformly poor, with median overall survival of 2.7 months for acute and 5.2 months for lymphoma ATL. In multivariate analysis, acute ATL subtype

SUBMITTER: Ramassamy JL 

PROVIDER: S-EPMC12811218 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature