Neuronal Sik1 in the Hypothalamic Paraventricular Nucleus Decreases Blood pressure Elevation Following a High-Salt Diet.

ABSTRACT: Blood pressure (BP) regulation involves complex interactions between peripheral organs and the brain. As a key area gating BP regulation, how the hypothalamic paraventricular nucleus (PVN) modulates salt‑sensitive hypertension remains unclear. Here, we found that Sik1, a member of the AMP-activated protein kinase family, was upregulated in PVN neurons of mice following a high-salt diet (HSD). When Sik1 was ablated, Sik1 knockout mice exhibited an increase in BP upon HSD feeding. Furthermore, specific deletion of the Sik1 gene in the nervous system by Nestin-Cre (Nestin-Cre;Sik1^-/-) resulted in elevated BP after high salt intake. Notably, AAV-Cre-mediated selective ablation of Sik1 in the PVN neurons was sufficient to cause BP elevation following an HSD. In combination with weste

SUBMITTER: Zhang W 

PROVIDER: S-EPMC12811292 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature