Development of Insulin and Leptin Resistance in the Mouse Brainstem with Age.

ABSTRACT: Physiological aging involves a progressive deterioration of homeostatic mechanisms that cause obesity and defective glucose homeostasis, which develop age-related diseases increasing mortality risk and reducing lifespan. The brainstem is involved in glucose and metabolic homeostasis by integrating peripheral signals such as insulin and leptin. Here, we evaluated the brainstem response to intracerebroventricular administration of insulin or leptin and the relationship with physiological levels of key molecules implicated in their signal transduction pathway and inflammation in 3-, 6-, and 12-month-old mice which progressively increase adiposity and develop signs of insulin resistance. The initial steps of insulin and leptin signaling pathways decline with age, as well as the protein kinase

SUBMITTER: De Frutos Gonzalez E 

PROVIDER: S-EPMC12811305 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature