Mediating role of metabolic dysfunction-associated fatty liver disease in the association between individual-level noise exposure and liver enzymes in Chinese automotive manufacturing workers.

ABSTRACT:

Background

Limited research has explored the relationship between occupational noise exposure and liver enzymes, particularly at the individual exposure level. This study examines the association between occupational noise exposure and liver enzyme levels and the mediating role of metabolic dysfunction-associated fatty liver disease (MAFLD).

Methods

We recruited 3,427 workers from two factories in Guangzhou, China. Cumulative noise exposure (CNE) was estimated based on noise levels and years of exposure. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), and γ-glutamyl transferase (GGT) levels were obtained from medical examinations. Linear and logistic regression models, along with subgroup and mediation analyses, were employed to assess the associations betw

SUBMITTER: Ou S 

PROVIDER: S-EPMC12811319 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature