Cognitive training, exercise training or combined training? A comparative effectiveness research study on subjective and objective cognitive outcomes in multiple sclerosis.

ABSTRACT:

Objective

Cognitive impairment (CI) in people with multiple sclerosis (pwMS) may be present from the onset, is common, and has a profound impact on those affected. This study compared the effectiveness of three different therapeutic approaches (computerized cognitive training, BrainStim (BS); treadmill walking (TW); combined training (BS + TW)) on subjective and objective cognitive functioning in pwMS and CI.

Methods

61 pwMS were recruited from the Department of Neurology outpatient clinic of the University Hospital Düsseldorf and neurologists in private practice. After screening for eligibility, pwMS were randomized into three treatment arms: 1) BS, 2) TW, 3) BS + TW. Subjective and objective cognitive functioning were evaluated before and after intervention, including the

SUBMITTER: Gyger N 

PROVIDER: S-EPMC12811355 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature