The m6A methyltransferase METTL14 promotes oncogenic Kras induced juvenile myelomonocytic leukemia through dysregulating autophagy.

ABSTRACT: The N6-methyladenosine (m6A) modification plays an important role in the pathogenesis of various myeloid malignancies. However, its specific role in RAS mutation-induced myeloid malignancy is incompletely understood. In this study, we found that m6A methyltransferase methyltransferase-like 14 (METTL14) was highly expressed and associated with a shorter survival in a RAS-mutation myeloid malignancy, juvenile myelomonocytic leukemia (JMML). The knockout of METTL14 was revealed to significantly promote hematopoietic stem/progenitor cells (HSPCs) expansion and suppresses disease progression in a Kras^G12D/+ mutation-induced mouse model of JMML. Moreover, knockout of METTL14 reduces hyperproliferation of Kras^G12D/+ HSPCs and suppresses oncogenic Kras^G12D/+-induce

SUBMITTER: Zhang P 

PROVIDER: S-EPMC12811360 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature