BRCA1 and BRCA2 gene expression: p53- and cell cycle-dependent repression requires RB and DREAM.

ABSTRACT: BRCA1 and BRCA2 proteins are crucial for DNA repair through homologous recombination (HR), which predominantly takes place during S and G₂ phases. Their expression is tightly regulated to ensure HR occurs exclusively within these phases. While these proteins are well-established tumor suppressors in hereditary breast and ovarian cancers, their inactivation is rare across all sporadic cancers. Counterintuitively, BRCA1 and BRCA2 expression is downregulated rather than upregulated following DNA damage and p53 activation. In this study, we demonstrate that BRCA1 and BRCA2 gene expression is governed by the same transcriptional mechanisms throughout the cell cycle, peaking in the S phase. During G₀/G₁ and following p53 activation, BRCA1/2 transcription is repre

SUBMITTER: Quaas M 

PROVIDER: S-EPMC12811384 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature