Epithelial pyroptosis-induced TREM1⁺ macrophages activate Th17 cells to accelerate oral mucosal inflammation.

ABSTRACT: Chronic inflammation of the oral mucosa could affect daily living and even threaten systemic health. Unlike periodontitis, oral lichen planus, a common oral chronic inflammatory disease, has diverse clinical manifestations and can progress to malignancy. Hence, this study aimed to investigate the mechanism of oral chronic inflammation using single-cell RNA sequencing (scRNA-seq), spatial transcriptome, a large clinical follow-up cohort with bulk RNA sequencing, cytological experiments, and multiplex immunohistochemistry. We found that epithelial pyroptosis-induced triggering receptor expressed on myeloid cell-1 (TREM1)⁺ macrophages activated pathogenic T helper cell 17 via interleukin-1β, to spur the inflammatory development of oral mucosal epithelium. Besides, we established a

SUBMITTER: Shang Q 

PROVIDER: S-EPMC12811386 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature