Epigenetic and blood markers associated with response to electroconvulsive therapy in patients with depressive disorders.

ABSTRACT: Electroconvulsive therapy (ECT) is an effective antidepressant treatment. The mechanisms behind the therapeutic effect are not fully understood, and reliable biomarkers for response are needed. Epigenetic modifications, such as DNA methylation (DNAm), can reflect both genetic and environmental impacts; they may shed light on the mechanisms behind treatment effects and they have the potential to inform response prediction. We performed an epigenome-wide association study (EWAS) in peripheral blood from patients before and after ECT in a Norwegian cohort (n = 65). The methylation levels of 12 differentially methylated CpG positions (DMPs) and 18 differentially methylated regions (DMRs) were significantly associated with percent clinical response. In addition, 29 DMPs and 23 DMRs were signifi

SUBMITTER: Stavrum AK 

PROVIDER: S-EPMC12811393 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature