Deconstruction by <i>C. thermocellum</i>-from microbe mediated to dynamic redistribution of cellulosomes.

ABSTRACT: Clostridium thermocellum is one of the most efficient microorganisms for the deconstruction of cellulosic biomass. To achieve this high level of cellulolytic activity, C. thermocellum uses large multienzyme complexes known as cellulosomes to break down complex polysaccharides, notably cellulose, found in plant cell walls. The attachment of bacterial cells to the nearby substrate via the cellulosome has been hypothesized to be the reason for this high efficiency. The region lying between the cell and the substrate has shown great variation and dynamics that are affected by the growth stage of cells and the substrate used for growth. Here, we used both super-resolution imaging and machine-learning approaches to study the distribution of C. thermocellum cellulosomes at di

SUBMITTER: Yarbrough JM 

PROVIDER: S-EPMC12811415 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature