Efficacy and safety of antihypertensive drugs deprescribing in older adults: A systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Although antihypertensive therapy is beneficial, aggressive treatment in frail, multimorbid older adults may increase adverse outcomes such as falls and hypotension. Deprescribing has emerged as a potential strategy to reduce these risks, but evidence regarding its safety remains limited. This systematic review and meta-analysis assessed the clinical outcomes of antihypertensive deprescribing in older adults.

Methods

PubMed, Scopus, CENTRAL, and Web of Science were searched for randomized controlled trials (RCTs) published up to October 2025 comparing antihypertensive deprescribing with usual care. Primary outcomes were all-cause mortality, cardiovascular mortality, and all-cause hospitalizations. Secondary outcomes included major adverse cardiovascular events (MA

SUBMITTER: Alsubaiei AA 

PROVIDER: S-EPMC12811430 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature