Time-dependent prognostic improvement by late gadolinium enhancement in dilated cardiomyopathy.

ABSTRACT:

Background

Dilated cardiomyopathy (DCM) represents a major cause of heart failure (HF), but current HF prediction models lack validation in DCM cohorts. Late gadolinium enhancement (LGE) predicts mortality in DCM patients. The incremental value of LGE to existing models warrants exploration.

Methods

In this single-center cohort study, hospitalized patients with DCM who underwent cardiac magnetic resonance (CMR) between June 2012 and August 2020 were included. We externally validated five published HF models as follows: SHFM, GISSI-HF, MAGGIC, BIOSTAT-CHF, and PREDICT-HF. The composite endpoints were all-cause mortality and heart transplantation. We then developed three LGE-enhanced models by integrating LGE presence, location, and patterns with risk scores from the published

SUBMITTER: Tang S 

PROVIDER: S-EPMC12811442 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature