Distinct treatment response trajectories to allergen immunotherapy in allergic asthma and rhinitis: Insights from a multicenter study in routine clinical practice.

ABSTRACT:

Background

While allergen-specific immunotherapy (AIT) is recognized as an effective treatment, its efficacy varies widely. However, whether clinical response trajectories to AIT differ among individuals and influence its effectiveness has not been investigated.

Objective

This study aimed to characterize real-world clinical response trajectories to three-year AIT (3y-AIT).

Methods

We conducted a retrospective multicenter study across 53 centers to identify clinical response trajectories in patients with house dust mite allergic asthma and rhinitis undergoing three-year AIT. The efficacy of AIT was primarily assessed using the Visual Analog Scale (VAS) for allergic symptoms at 4 time points: baseline (before AIT), and at 1, 2, and 3 years of treatment. Clustering analy

SUBMITTER: Zhang P 

PROVIDER: S-EPMC12811459 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature