The antivirulence effect of 5-iodoindole on <i>Vibrio splendidus</i> AJ01 towards <i>Apostichopus japonicus</i>.

ABSTRACT: Vibrio splendidus AJ01 is the primary pathogen of Apostichopus japonicus, resulting in huge economic losses. In the present study, we found that 5-iodoindole exhibits a remarkable protective effect on A. japonicus, the survival rate of which can be improved to 93.75%. To explore the impact of 5-iodoindole on V. splendidus AJ01, bacterial growth and virulence factors were determined. Results showed that 5-iodoindole significantly decreased swimming motility, hemolytic activity and protease activity but had minimal effect on the overall growth of the bacterium. Furthermore, a differentially expressed protein was downregulated and identified as elongation factor thermo unstable protein (EF-Tu) via SDS-PAGE combined with LC-MS/MS. Moreover, 5-iodoindole had impact o

SUBMITTER: Wu Z 

PROVIDER: S-EPMC12811495 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature