Bridging the self to the world: resting-state functional connectivity of the temporoparietal junction in post-traumatic stress disorder and its dissociative subtype.

ABSTRACT:

Background

The temporoparietal junction (TPJ) is a cross-network hub involved in social cognition and attention, processes which are directly impacted by symptoms observed in clinical profiles of post-traumatic stress disorder (PTSD) and its dissociative subtype (PTSD + DS).

Methods

Using SPM12 and CONN, seed-based TPJ resting-state functional connectivity patterns were analyzed in individuals with PTSD (n = 81), PTSD + DS (n = 49), and healthy controls (n = 54) using four seeds [right anterior TPJ (raTPJ), left anterior TPJ (laTPJ), right posterior TPJ (rpTPJ), left posterior TPJ (lpTPJ)]. Post-hoc graph theoretical analyses were performed for raTPJ connectivity in PTSD + DS and healthy controls.

Results

As compared to healthy controls, PTSD + DS showed decreased raT

SUBMITTER: Narikuzhy S 

PROVIDER: S-EPMC12811541 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature