Cost-Effectiveness of Risk-Based Screening for Asymptomatic Carotid Artery Stenosis.

ABSTRACT: Background. Extracranial internal carotid artery stenosis (50%-99% arterial narrowing) is an important risk factor for ischemic stroke. Yet, the benefits and harms of targeted screening for asymptomatic carotid artery stenosis (ACAS) have not been assessed in population-based studies. We aimed to estimate the cost-effectiveness of one-time, targeted ACAS screening stratified by atherosclerotic cardiovascular disease (ASCVD) risk using the American Heart Association's pooled cohort equations. Methods. We developed a lifetime microsimulation model of ACAS and stroke for a hypothetical cohort representative of US adults aged 50 to 80 y without stroke history. Model parameters were derived from multiple cohort studies and the published literature. Outcomes included estimated stro

SUBMITTER: Zhu J 

PROVIDER: S-EPMC12811569 | biostudies-literature | 2026 Jan-Jun

REPOSITORIES: biostudies-literature