Efficacy and safety of Busulfan-Fludarabine versus Busulfan-Cyclophosphamide as a conditioning regimen prior to hematopoietic stem cell transplant in hematologic malignancy patients: a meta-analysis of randomized controlled trials and observational studies.

ABSTRACT:

Background

Conditioning regimen selection significantly impacts the outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) in patients with hematologic malignancies. However, comparative evidence between Busulfan-Fludarabine and Busulfan-Cyclophosphamide remains inconclusive.

Objectives

To compare the efficacy and safety of Busulfan-Fludarabine versus Busulfan-Cyclophosphamide as conditioning regimens prior to HSCT.

Design

Systematic review and meta-analysis conducted in accordance with PRISMA 2020 guidelines.

Data sources and methods

MEDLINE, CENTRAL, and Embase were searched through October 2024. Eligible studies included randomized controlled trials and cohort studies comparing Busulfan-Fludarabine and Busulfan-Cyclophosphamide in HSCT recipie

SUBMITTER: Ali A 

PROVIDER: S-EPMC12811581 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature