Lesion locations are associated with cognitive impairment after ischemic stroke in young adults.

ABSTRACT:

Introduction

Stroke location is an important determinant of post-stroke cognitive impairment (PSCI). In young adults, a comprehensive map of lesion patterns and their relations to PSCI is lacking. This study aims to identify lesion locations associated with poorer cognitive performance in patients with stroke at a young age.

Methods

We conducted a multicenter prospective cohort study between 2013 and 2021, enrolling patients aged 18-49 years with first-ever ischemic stroke and a visible stroke lesion on MRI. Cognitive assessments were performed within six months post-stroke, covering seven domains. We categorized patients as having no/mild or major vascular cognitive disorder (VCD), defined as a Z-score < -2.0 in one or more domains. We assessed aphasia by the NIHSS language

SUBMITTER: Schellekens MMI 

PROVIDER: S-EPMC12811597 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature