LncRNAs as Emerging Diagnostic Biomarkers for Cardiovascular Diseases: Evidence Synthesis Through Systematic Review and Meta-Analysis.

ABSTRACT: BackgroundCardiovascular diseases (CVDs) are the leading cause of global morbidity and mortality. Long non-coding RNAs (lncRNAs) have emerged as potential diagnostic biomarkers for CVDs.AimTo systematically evaluate the diagnostic value of lncRNAs for CVDs through a systematic review and meta-analysis.MethodsStudies focusing on lncRNAs as diagnostic markers for CVDs were searched from PubMed, Embase, and Web of Science databases. The meta-analysis was conducted according to the PRISMA 2020 guidelines. The diagnostic value of lncRNAs was calculated by pooled sensitivity, specificity, and area under the summary receiver operating characteristic (SROC) curve (AUC). Meta-regression and subgroup analyses were performed to explore heterogeneity sources. Publication bias and sensitivity analysis

SUBMITTER: Zhu B 

PROVIDER: S-EPMC12811601 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature