LncRNA PVT1 promotes proliferation, migration and invasion of cholangiocarcinoma by regulating the expression of SOCS2.

ABSTRACT: Cholangiocarcinoma, a malignant tumor originating from the bile duct epithelium, poses significant therapeutic challenges and is often associated with poor prognosis. This study aims to elucidate the relationship between plasmacytoma variant translocation 1 (PVT1), a long non-coding RNA implicated in cancer progression, and suppressor of cytokine signaling 2 (SOCS2), recognized for its tumor-suppressive properties. Utilizing the GEPIA2 database, we investigated the expression levels of PVT1 and SOCS2 in cholangiocarcinoma specimens and cell lines through quantitative real-time PCR (qRT-PCR) and Western blotting. Our results demonstrated that PVT1 expression was markedly upregulated in cholangiocarcinoma tissues and cells, while SOCS2 was significantly downregulated. Functional assays revea

SUBMITTER: Cao X 

PROVIDER: S-EPMC12811614 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature