Refining mechanistic models of hallucinations for enhanced translatability.

ABSTRACT: Over the past two decades, foundational work has provided key insights into the cognitive and neural basis of hallucinations. This progress has led to the development of several families of theories, each of which propose that hallucinations arise from distinct cognitive mechanisms. Since these cognitive mechanisms likely map onto separate circuit-level implementations, arbitrating between them is critical to advance our understanding of hallucination pathophysiology and guide the development of novel targeted therapeutics. However, several obstacles have hindered this progress, including the under-specification of theories and inadequate comparative testing. To overcome these challenges, and following best practices in cognitive computational neuroscience, theories should 1) articulate co

SUBMITTER: Buck J 

PROVIDER: S-EPMC12811618 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature