Supramolecular Carbohydrate Assemblies with Tunable Glycan Surfaces.

ABSTRACT: The self-assembly of molecular building blocks into ordered supramolecular structures enables the creation of nanomaterials that can display ligands on their surfaces with molecular precision. However, many of these supramolecular scaffolds face challenges in incorporating bulky or hydrophilic ligands, such as carbohydrates. This issue often requires the co-assembly of ligand-containing blocks with non-functionalized ones, diluting ligand presentation and compromising their precise spatial arrangement. Herein, we present carbohydrate oligomers that assemble into supramolecular nanomaterials featuring a molecularly controlled, dense presentation of carbohydrate ligands on their surfaces. This modular system accommodates a variety of carbohydrate ligands while maintaining consistent bulk mat

SUBMITTER: Hribernik N 

PROVIDER: S-EPMC12811653 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature