Simulating tDCS-induced electric fields in stroke patients: Realistic-lesion head models are needed.

ABSTRACT:

Introduction

Transcranial direct current stimulation (tDCS) is tested as tool for post-stroke rehabilitation in aphasia, and individualized simulations of tDCS-induced electric fields (E-fields) can guide its application. However, the accuracy of simulations is challenged by complex and variable tissue properties of stroke lesions. Here, we assessed the impact of stroke lesions on tDCS-induced E-fields realistically in terms of lesion size, shape, and conductivity.

Methods

Structural and diffusion MRI datasets of stroke patients with aphasia (n = 13, six females, age = 38-70 years) and age-matched healthy controls (n = 13, eight females, age = 24-76 years) from a previous study were analyzed. Simulated E-fields were first compared between healthy head models with and without

SUBMITTER: Kimura I 

PROVIDER: S-EPMC12811680 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature