Replication competent La Crosse virus pseudotyped VSV vector system as vaccine and serological diagnostic reagent.

ABSTRACT: La Crosse encephalitis virus (LACV) is the second most frequently diagnosed arboviral cause of meningoencephalitis and the most common cause of pediatric viral encephalitis in the US. Multiple factors, including climate changes and invasive mosquito species adaptation contribute to the emerging spread of LACV in new areas. There is an expanding need for broader investigation on seroprevalence, development of novel antiviral drugs and vaccines for prevention of LACV infection. We pseudotyped replication-competent vesicular stomatitis virus (VSV) vectors with LACV surface glycoproteins using wild type (VSV-LACV) and attenuated (VSV-M51-LACV) backbones. Recombinant strains were tested as diagnostic tools in LACV serology and as potential live anti-LACV vaccine in vivo. The attenuated VSV-M51R

SUBMITTER: Iankov I 

PROVIDER: S-EPMC12811681 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature