Drug-Inspired Design of Supramolecular Polymers for Enhanced Drug Loading and Sustained Therapeutic Release.

ABSTRACT: Supramolecular polymeric hydrogels have emerged as a dynamic, versatile platform for localized therapeutic delivery, leveraging reversible and tunable noncovalent interactions. Despite their potential, designing supramolecular polymers that combine high drug loading with sustained, controlled release remains a considerable challenge. Here, we introduce a series of drug-inspired, peptide-based monomers engineered as supramolecular hydrogelators to facilitate high-affinity coassembly with therapeutic agents. By strategically utilizing electrostatic complexation and π-π stacking interactions, these hydrogelators self-assemble into robust supramolecular polymer networks with well-defined nanostructures, achieving nearly 100% fingolimod loading efficiency and extremely high loading capacity (up

SUBMITTER: Sun B 

PROVIDER: S-EPMC12811758 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature