Associations of circulating c-reactive protein levels with central Alzheimer's disease biomarkers.

ABSTRACT:

Background

C-reactive protein (CRP) is well-known marker of inflammation and immune response. Its potential role in Alzheimer's disease (AD) pathophysiology remains unclear, particularly in relation to central AD biomarkers, including beta-amyloid (Aβ), tau, and neurodegeneration.

Objectives

To investigate the associations between circulating CRP levels and central AD biomarkers-including Aβ deposition, tau, and AD-signature neurodegeneration-in nondemented older adults.

Design, setting, participants

This cross-sectional observational study analyzed data from a Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer Disease conducted from 2014 to 2020. A total of 417 nondemented older adults underwent comprehensive evaluations, including blood samplin

SUBMITTER: Choi HJ 

PROVIDER: S-EPMC12811776 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature