Progression to Decompensation of Severe Fibrosis Compared to Cirrhosis in MASLD: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background & aims

Metabolic associated steatotic liver disease (MASLD) is increasing in prevalence worldwide. Clinical practice is focused on identifying those with cirrhosis and monitoring for complications such as varices and hepatocellular carcinoma (HCC). Non-invasive tests of fibrosis differentiate between F3 and F4 fibrosis poorly. People with F3 fibrosis may progress and develop decompensated liver disease. The aim of this review is to examine the progression to decompensated liver disease in patients with F3 fibrosis compared to those with F4 fibrosis.

Methods

Searches were carried out in four databases; articles were screened by two independent reviewers against pre-specified inclusion and exclusion criteria.

Results

Twenty-nine studies were included in the r

SUBMITTER: Barrett R 

PROVIDER: S-EPMC12811796 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature