Neuropathologic Profiles and Associated Cognitive Trajectories in Community-Living Older Adults.

ABSTRACT:

Importance

Mixed neuropathologies are common, and yet the full extent to which these pathologies coexist is not entirely clear.

Objectives

This study aims to identify distinct neuropathologic profiles in community-dwelling older adults and to examine associated cognitive trajectories over time.

Design, setting, and participants

This study included participants in 2 community-based cohort studies of aging and dementia. Participants were older adults without known dementia at enrollment who agreed to annual evaluations and brain donation. The Religious Orders Study started in 1994, and the Rush Memory and Aging Project started in 1997. Both studies are ongoing. Data were analyzed in May 2025.

Exposures

Annual uniform detailed evaluations for up to 30 years and br

SUBMITTER: Yu L 

PROVIDER: S-EPMC12811812 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature