The Burden of Surgical Site Infections With Pathogens Presumably Resistant to Perioperative Prophylaxis in Orthopedic Tumor Surgery: Secondary Analysis of the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Trial.

ABSTRACT:

Background

Surgical procedures for malignant bone tumors of the lower extremity are associated with a significant risk of surgical site infection (SSI). Little is known about the microbiology and risk factors for resistant SSIs in this population.

Methods

We describe the microbiological and other characteristics and of SSIs, as well as risk factors for antimicrobial resistance against antibiotics used for perioperative prophylaxis in a secondary analysis of the Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) trial population. The PARITY trial assessed the effects of short-term (24 hour) versus long-term (5-day) postoperative antibiotic prophylaxis on the SSI incidence in orthopedic oncology.

Results

SSIs were identified in 96 of 604 patients (15.9%), with ≥

SUBMITTER: Kuster S 

PROVIDER: S-EPMC12811854 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature