Emergence of ST3390: A Novel Apigmented MRSA Clone From the CC5 Lineage.

ABSTRACT:

Background

One of the most successful and widely-distributed hospital-associated lineages of MRSA is clonal complex 5 (CC5). These strains are known for widespread antibiotic resistance but less severe disease than CA-MRSA counterparts. Recently, CC5 descendant lineages have appeared globally with hypervirulent properties. Herein, we identify and characterize a rare and novel CC5 MRSA sequence type, ST3390.

Methods

We used whole genome sequencing, alongside phenotypic characterizations, genetic complementation, blood viability- and neutrophil-killing assays, and a murine model of sepsis to study the pathogenic capabilities of ST3390 strains.

Results

To date, there have only been 65 recorded instances of infection caused by ST3390 globally, with 36 of those occurring i

SUBMITTER: Felton EA 

PROVIDER: S-EPMC12811862 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature