Culture and Adaptation of Pseudomonas aeruginosa During Early Infection in Children With Cystic Fibrosis.

ABSTRACT:

Background

Relatively little is known about Pseudomonas aeruginosa lineages during early infection in individuals with cystic fibrosis (CF). The Early Pseudomonas Infection Control Clinical Trial (EPIC-CT), which treated individuals with CF and newly detected P. aeruginosa infections, presents an ideal opportunity to study this phenomenon.

Methods

We performed whole-genome sequencing on 572 P. aeruginosa isolates from 190 EPIC-CT subjects.

Results

We identified 203 P. aeruginosa lineages causing newly detected infections near the time of enrollment of these subjects. Twelve subjects were initially infected with more than one P. aeruginosa lineage, and 20 subjects had different PA lineages detected during the follow-up period of the EPIC-CT. Of the 203 lineages causing

SUBMITTER: Mitra SD 

PROVIDER: S-EPMC12811872 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature