Impact of proton vs. photon radiotherapy on overall survival in the management of spinal chondrosarcoma and mortality risk prediction: A nationwide analysis.

ABSTRACT:

Background

Spinal chondrosarcomas are rare, aggressive bone tumors with limited data on optimal radiotherapy strategies, particularly regarding the comparison between proton and photon therapies. This study aims to evaluate long-term survival outcomes and identify effective treatments and risk factors using the National Cancer Database.

Methods

Patients diagnosed with spinal chondrosarcomas were categorized into radiation and no-radiation groups. The radiation group was subdivided into proton and photon therapy cohorts. Univariate and Kaplan-Meier analyses assessed demographic, clinical, and survival outcomes. Multivariate Cox proportional hazards models identified prognostic factors, and survival predictive models were evaluated using Area Under the Curve (AUC) metrics.

SUBMITTER: Ghaith AK 

PROVIDER: S-EPMC12812003 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature