Persistent severe acute kidney injury is a major modifiable determinant of outcome during critical illness.

ABSTRACT:

Rationale

Most cases of acute kidney injury (AKI) resolve within 72 h. However, a small number of patients with persistent severe AKI have significantly worse outcomes. We sought to describe the occurrence, impact on outcome and risk factors associated with persistent severe AKI in critically ill patients using a standardized definition.

Methods

Retrospective cohort study, investigating critically ill patients admitted to one of 16 hospitals from October 2010 to June 2018. We defined persistent severe AKI as Kidney Disease: Improving Global Outcomes stage 2-3 AKI that progressed to and persisted at stage 3 for ≥ 72 h. Risk factors for persistent severe AKI and its association with outcomes were assessed using the super learner algorithm, integrating LASSO logistic regression

SUBMITTER: Gomez H 

PROVIDER: S-EPMC12812024 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature