Non-invasive modelling and parametric methods for quantification of MAO-B activity using [¹¹C]L-deprenyl-D2 PET.

ABSTRACT: The PET radioligand [¹¹C]L-deprenyl-D2 binds to monoamine oxidase B (MAO-B), enabling studies of neuroinflammation in various neurological disorders. This study aimed to evaluate non-invasive and parametric methods for quantifying [¹¹C]L-deprenyl-D2 PET. Twenty-eight subjects underwent 60 min dynamic [¹¹C]L-deprenyl-D2 PET. The irreversible binding parameter λk₃ and the net influx rate relative to the non-displaceable volume of distribution K_ND were estimated with an irreversible two-tissue plasma-input compartment model (2T3k). Non-invasive quantification of K_ND was performed using cerebellum corrected for specific binding with previously suggested corrections as reference tissue. These corrections were

SUBMITTER: Hedman K 

PROVIDER: S-EPMC12812065 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature