Efficacy and safety of esketamine for sedation during colonoscopy: A systematic review and Meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Hemodynamic instability during colonoscopy sedation remains a significant clinical concern. Esketamine's sympathomimetic properties may protect against these risks while reducing sedative requirements. Hence, we aim to evaluate the efficacy and safety of esketamine in improving intraprocedural sedation during colonoscopy.

Methods

We systematically searched PubMed, Scopus, CENTRAL, and Web of Science until June 2025 for randomized controlled trials. The primary outcome was the incidence of intraprocedural hypotension; secondary outcomes included bradycardia, hypoxemia, and recovery parameters. Dichotomous outcomes were pooled using risk ratios (RR) and continuous outcomes using standardized mean differences (SMD), with heterogeneity assessed via I² statistics.

P

SUBMITTER: Hussein Z 

PROVIDER: S-EPMC12812101 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature