Determinants of circulating PCSK9 levels and the efficacy of PCSK9 inhibitor therapies in chronic kidney disease: a systematic review.

ABSTRACT:

Purpose of review

Chronic kidney disease (CKD) significantly increases the risk of atherosclerotic cardiovascular disease (ASCVD), with dyslipidemia-particularly elevated low-density lipoprotein cholesterol (LDL-C)-being a shared risk factor. While statin-based therapies are effective in early-stage CKD, their benefits in dialysis and kidney transplant patients remain inconclusive. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of lipid metabolism. This review aims to summarize the factors influencing PCSK9 levels in CKD patients and evaluate the safety and efficacy of PCSK9 inhibitors across different stages of CKD.

Recent findings

Multiple factors have been associated with variations in plasma PCSK9 concentrations in CKD, including glycemic status

SUBMITTER: Abel T 

PROVIDER: S-EPMC12812102 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature