Inhibition of BMPER Mitigates Pulmonary Hypertension by Modulating LRP1-YAP Interaction in Smooth Muscle Cells.

ABSTRACT:

Background

BMPER (bone morphogenetic protein-binding endothelial regulator) is a secreted protein that is highly expressed in endothelial cells. It regulates the BMP (bone morphogenetic protein) pathway during vascular development and adulthood. Mutations in the BMP pathway are recognized as risk factors for pulmonary arterial hypertension group 1 pulmonary hypertension (PH). However, the roles of BMPER in pulmonary arterial hypertension remain unknown.

Methods

We assessed BMPER expression in Group 1 pulmonary arterial hypertension patient samples and examined its role in vascular remodeling using in vivo and in vitro approaches.

Results

BMPER level was elevated in pulmonary arterial hypertension lungs and significantly associated with pulmonary vascular resistance, b

SUBMITTER: Mao H 

PROVIDER: S-EPMC12812256 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature