Asymmetric Rh-Catalyzed Synthesis of Dihydronicotinamides.

ABSTRACT: We report a rhodium-catalyzed enantioselective dearomatization of nicotinamide-derived pyridinium salts to access primary, secondary, and tertiary dihydropyridine carboxamides with high regio- and enantioselectivity (up to 99% ee). Employing arylboronic acid pinacol esters and Rh/(R)-Xyl-BINAP, the reaction tolerates diverse functional groups, enabling a versatile approach for synthesizing chiral azaheterocycles with pharmaceutical relevance.

SUBMITTER: Zerangnasrabad S 

PROVIDER: S-EPMC12812258 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature