Association of an Algorithm-Generated Medication Optimization Score With Clinical Outcomes in Ambulatory Patients With Heart Failure.

ABSTRACT:

Aims

Guideline-directed medical therapy (GDMT) implementation in heart failure with reduced ejection fraction (HFrEF) remains suboptimal. A computable algorithm was developed to generate a medication optimization score (MOS) and provide guideline-based recommendations. This computable algorithm was previously validated using clinical trial data, and an updated version was developed in 2021 to include sodium-glucose co-transporter 2 inhibitors. This study evaluated the association between the medication optimization information generated by this version of the algorithm and clinical outcomes using real-world data.

Methods

We conducted a retrospective cohort study of 1352 ambulatory adult patients with chronic HFrEF who received care from the advanced heart failure service at

SUBMITTER: Ali MS 

PROVIDER: S-EPMC12812323 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature