Parietal cortex is causally required for state-dependent decisions.

ABSTRACT: During perceptual decision-making, behavioral performance varies with internal states like arousal, motivation, and strategy, but how these fluctuations impact distributed neural processes remains unclear. We trained mice on a navigation-based sound-localization task and examined how behavioral performance state changes relate to neural processing in cortex. Hidden Markov modeling shows that expert mice alternate between a high-performance state with optimal stimulus weighting and low-performance states characterized by high choice bias. Optogenetic inactivation of the posterior parietal cortex (PPC) decreases task accuracy and increases occupation of biased performance states. Two-photon calcium imaging shows that performance states strongly influence population activity in the PPC but no

SUBMITTER: Bandi AC 

PROVIDER: S-EPMC12812442 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature