Comparison of interventions for intermediate to high-risk pulmonary embolism: A network meta-analysis.

ABSTRACT:

Background

Multiple interventions, including catheter-directed therapy (CDT), systemic thrombolysis (ST), surgical embolectomy (SE), and therapeutic anticoagulation (AC) have been used to treat intermediate to high-risk pulmonary embolism (PE), but the most effective and safest treatment remains unclear. Our study aimed to investigate the efficacy and safety outcomes of each intervention.

Methods

We queried PubMed and EMBASE in January 2023 and performed a network meta-analysis of observational studies and randomized controlled trials (RCT), including high or intermediate-risk PE patients, and comparing AC, CDT, SE, and ST. The primary outcomes were in-hospital mortality and major bleeding. The secondary outcomes included long-term mortality (≥6 months), recurrent PE, minor

SUBMITTER: Ishisaka Y 

PROVIDER: S-EPMC12812479 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature