SARS-CoV-2 spike sequence-based distance as a marker of binding antibody response to COVID-19 vaccines.

ABSTRACT: COVID-19 vaccines based on ancestral SARS-CoV-2 have proven highly effective at reducing the risk of illness, especially severe disease. Both binding and neutralizing antibodies have been demonstrated to be strong predictors of the level of vaccine efficacy (VE). Both VE and vaccine-induced antibody responses have been shown to be lower against emergent SARS-CoV-2 viruses; therefore, predicting COVID-19 VE against emergent viruses is critical for decision-making regarding the composition of new vaccines. The data needed to enable such prediction are unclear. We report on 728 individuals without prior SARS-CoV-2 infection who received primary vaccination with ancestral-virus-based mRNA and vector-based COVID-19 vaccines and who were boosted in a homologous or heterologous fashion with mRNA,

SUBMITTER: Dominguez Islas CP 

PROVIDER: S-EPMC12812481 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature