Updated Neuronal Numbers of the Rat Hippocampal Formation: Redesigning the Hippocampal Model.

ABSTRACT: The hippocampal formation is a functional entity that includes the hippocampus, subicular complex, and the entorhinal cortex, and has an essential role in learning and memory, emotional processing, and spatial coding. The well-defined structure of hippocampal fields and the segregation of the connections have made this structure a favorite candidate for functional models that rely on fundamental information such as the number of neurons populating the hippocampal fields. Existing models on the rat rely on neuronal populations obtained from single studies, so we aimed to obtain more representative estimates by analyzing all available data. We identified 89 studies using reliable methodology that provided 264 stereological estimates of principal neuron populations. The resulting averages for

SUBMITTER: Arellano JI 

PROVIDER: S-EPMC12812505 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature