Digital spatial profiling identifies features of primary and locoregional metastatic vasculature in triple negative breast cancer.

ABSTRACT: Triple Negative Breast Cancer (TNBC) is an aggressive subtype of breast cancer with limited treatment options and poor prognosis. Coupled with this, TNBC shows a high rate of metastasis which is known to be aided by tumour vasculature. Endothelial cells that form the lining of the tumour vasculature exhibit distinct genotype and phenotype differences compared with normal tissue vasculature. However, little is known about endothelial signatures that drive metastasis from a primary tumour, particularly in the context of immune infiltration. In this study, we utilized GeoMX Digital Spatial Profiling to investigate spatial proteomics differences in endothelial cells between primary and secondary sites of TNBC. By segmenting tissues using epithelial (PanCK), immune (CD45), and endothelial (CD31

SUBMITTER: Ravichandran A 

PROVIDER: S-EPMC12812774 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature