Effect of tau burden and Lewy pathology on neuropsychiatric symptoms in Aβ-positive individuals.

ABSTRACT:

Introduction

Neuropsychiatric symptoms (NPS) are common across the Alzheimer's disease (AD) spectrum. We aimed to evaluate the effects of amyloid beta (Aβ), tau, and Lewy body (LB) pathologies on NPS in Aβ-positive individuals.

Methods

In 336 Aβ-positive participants from the Alzheimer's Disease Neuroimaging Initiative cohort, spanning from cognitively unimpaired to those with early dementia, NPS were assessed. Aβ and tau positron emission tomography were conducted. In a subgroup of 238 participants, dichotomized LB pathology was assessed by detecting α-synuclein seeding activity. The effects of Aβ, tau, and LB pathologies on NPS were evaluated using logistic regression analyses.

Results

Greater tau burden was associated with delusion, agitation/aggression, irritabili

SUBMITTER: Kang S 

PROVIDER: S-EPMC12812851 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature