IL-22-STAT3-CD155 axis in alveolar echinococcosis: a pivotal role in immune exhaustion and therapeutic potential.

ABSTRACT:

Background

Alveolar echinococcosis (AE), a lethal zoonosis caused by Echinococcus multilocularis (E.m) infection, is characterized by immune exhaustion that facilitates parasite evasion of host immunity and sustains chronic infection. The role and mechanisms of Interleukin-22 (IL-22), a key immunomodulatory cytokine, in E.m-induced immune responses remain unclear and warrant investigation.

Methods

Liver tissue samples from AE patients and E.m-infected mouse models were utilized to investigate IL-22 expression dynamics during AE progression and its correlation with disease progression. Recombinant IL-22 (rIL-22) stimulation and IL-22-binding protein (rIL-22BP) blockade were integrated to comprehensively assess the role of IL-22 through Western blot

SUBMITTER: Li L 

PROVIDER: S-EPMC12813123 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature