TRPM6 acts as a prognostic biomarker and mediates Mg²⁺ dependent tumor suppression in colon adenocarcinoma.

ABSTRACT:

Introduction

Colon adenocarcinoma (COAD) is a malignant neoplasm derived from colonic epithelial cells with poor prognosis in advanced stages. This study aimed to identify critical molecular regulators of COAD and develop robust biomarkers for prognosis and therapy.

Methods

Transcriptome data from public databases were analyzed: differential expression of TRPM family genes in COAD and pan-cancer pathogenic associations of TRPM6 were assessed via the Wilcoxon test, with analyses of consensus molecular subtypes, clinical relevance, and survival also performed. TRPM6-regulated differentially expressed genes (DEGs) were identified for functional enrichment, and immune/tumor microenvironment correlations were evaluated using the Spearman test. In vitro, HCT116 and SW480 ce

SUBMITTER: Cao L 

PROVIDER: S-EPMC12813124 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature