Voriconazole-associated liver injury: clinical risk factor identification and predictive nomogram construction.

ABSTRACT:

Objective

Investigate the high risk factors contributed to voriconazole-induced liver injury and develop a predictive nomogram for voriconazole-induced liver injury risk, thereby optimizing the clinical medication safety.

Methods

This observational study retrospectively analyzed the electronic health records of hospitalized patients who received voriconazole treatment or prophylaxis at a tertiary hospital. Patients who met the inclusion and exclusion criteria were enrolled between June 2020 and June 2024, and their general biological data were collected. The diagnosis and severity grading of voriconazole-associated liver injury were determined according to the diagnostic and treatment guidelines for drug-induced liver injury. Patients were categorized into liver injury and n

SUBMITTER: Feng D 

PROVIDER: S-EPMC12813146 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature